Randomization Technique, Allocation Concealment, Masking, And Susceptibility Of Trials To Selection Bias
نویسندگان
چکیده
منابع مشابه
Eliminating bias in randomized controlled trials: importance of allocation concealment and masking.
Randomization in randomized controlled trials involves more than generation of a random sequence by which to assign subjects. For randomization to be successfully implemented, the randomization sequence must be adequately protected (concealed) so that investigators, involved health care providers, and subjects are not aware of the upcoming assignment. The absence of adequate allocation concealm...
متن کاملتصادفی سازی در مطالعات کارآزمایی بالینی: از تئوری تا عمل
Background & Aim: Randomized clinical trials (RCTs) are studies which are able to provide the most valid evidence to compare various interventions in health research. Biases can affect the quality of research and ultimately make the results of a study invalid. One of the most important biases is selection bias. The best way to reduce selection bias is the use of random allocation. The aim of th...
متن کاملEnsuring the comparability of comparison groups: is randomization enough?
BACKGROUND It is widely believed that baseline imbalances in randomized trials must necessarily be random. In fact, there is a type of selection bias that can cause substantial, systematic and reproducible baseline imbalances of prognostic covariates even in properly randomized trials. It is possible, given complete data, to quantify both the susceptibility of a given trial to this type of sele...
متن کاملInfluence of selection bias on the test decision. A simulation study.
BACKGROUND Selection bias arises in clinical trials by reason of selective assignment of patients to treatment groups. Even in randomized clinical trials with allocation concealment this phenomenon can occur if future assignments can be predicted due to knowledge of former allocations. OBJECTIVES Considering unmasked randomized clinical trials with allocation concealment the impact of selecti...
متن کاملOn the insufficiency of reporting masking.
Villamar et al. (1) noted that masking was reported at a higher rate in 2010 than it was in 2000, but lamented that other aspects of CONSORT were not similarly improved. To place the reporting of masking in context, imagine a scenario in which the rehabilitation of patients with knee injuries was considered complete and successful as soon as these patients reported feeling better. Imagine a pol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017